Hereditary spastic paraplegia associated with epilepsy, mental retardation and hearing impairment

Paraplegia. 1993 Jun;31(6):408-11. doi: 10.1038/sc.1993.68.


Epilepsy rarely occurs in patients with hereditary spastic paraplegia (HSP), and is not included in the description of the 'complicated' form of HSP by Harding. We report 3 patients with HSP in a family of two generations. Two of them also had epilepsy, mental retardation and hearing impairment. The disorder was inherited as an autosomal dominant trait.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Electroencephalography
  • Epilepsy / complications*
  • Epilepsy / genetics
  • Family
  • Female
  • Hearing Disorders / complications*
  • Hearing Disorders / genetics
  • Humans
  • Intellectual Disability / complications*
  • Intellectual Disability / genetics
  • Male
  • Neural Conduction / physiology
  • Spastic Paraplegia, Hereditary / complications*
  • Spastic Paraplegia, Hereditary / genetics