Forced expiratory flows and lung volumes in normal infants

Pediatr Pulmonol. 1993 Jun;15(6):357-61. doi: 10.1002/ppul.1950150608.


Forced expiratory flows at functional residual capacity (VmaxFRC) by the rapid compression technique and functional residual capacity (FRC) by the helium dilution technique were assessed in 112 normal infants with a mean age of 10.7 months (range, 1.0-31.0). In predicting FRC, log transformation was appropriate and body length was the best predicator. For VmaxFRC, age was a better predictor than length, and logarithmic transformation was not required. In(FRC) = -5.465 + 2.49 x In(length) SD = 0.178; r2 = 0.83 VmaxFRC = -397 + 9.36 x (age) SD = 88; r2 = 0.52 There were no gender differences for FRC or VmaxFRC; however, male infants exposed to passive cigarette smoke tended to have lower flows than male infants not exposed (P < 0.07). This study establishes normative values for VmaxFRC and FRC in infants between 1 and 31 months of age, and suggests that passive cigarette smoke exposure has an adverse effect upon forced expiratory flows in male infants.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Age Factors
  • Body Height
  • Child, Preschool
  • Family Health
  • Female
  • Forced Expiratory Flow Rates*
  • Forced Expiratory Volume*
  • Functional Residual Capacity
  • Humans
  • Infant
  • Infant, Newborn
  • Lung / physiology*
  • Lung Volume Measurements
  • Male
  • Predictive Value of Tests
  • Regression Analysis
  • Tobacco Smoke Pollution


  • Tobacco Smoke Pollution