Foveal avascular zone in diabetes mellitus

Retina. 1993;13(2):125-8. doi: 10.1097/00006982-199313020-00006.


The foveal avascular zone was measured angiographically in 144 subjects with diabetic retinopathy and 27 control subjects. Statistical significance was defined as P < 0.01. Quantitatively, the foveal avascular zone was significantly smaller in control eyes (median = 0.405 mm2) than in eyes with diabetic retinopathy, and smaller in eyes with background diabetic retinopathy (BDR; median = 0.737 mm2) than in eyes with proliferative diabetic retinopathy (PDR; median = 0.866 mm2) and preproliferative diabetic retinopathy (PPDR; median = 1.001 mm2). Qualitatively, the contour of the foveal avascular zone in diabetic retinopathy was irregular (29.2% of eyes with diabetic retinopathy vs 3.7% of control eyes) with scattered round microaneurysms. Diabetic retinopathy is characterized by an irregular, large foveal avascular zone with scattered microaneurysms.

MeSH terms

  • Adult
  • Diabetes Mellitus / pathology*
  • Diabetic Retinopathy / pathology*
  • Female
  • Fluorescein Angiography
  • Fovea Centralis / blood supply
  • Fovea Centralis / pathology*
  • Fundus Oculi
  • Humans
  • Hypertrophy
  • Male
  • Middle Aged
  • Photography