UV-B and the immune system. A review with special emphasis on T cell-mediated immunity

Thymus. 1993 Mar;21(2):93-114.


The immunosuppressive activity of ultraviolet light-B (UV-B) has become a major topic of interest, especially now that there are indications of an increased exposure to UV-B on the earth's surface, caused by a decreased thickness of the ozone layer. This review indicates that the thymus-dependent immune system is a prime target for damage by UV-B. Especially the systemic effects of UV-B on T cell mediated immunity are described and analyzed with respect to the mode of action. In summary, this review demonstrated that UV-B can alter T cell mediated immune responses by different pathways in which cytokines (e.g. TNF-alpha) and other soluble mediators (e.g. cis-urocanic acid) may play a role. Effects of UV-B on the location and morphology of different cells in the skin affect functionality of the immune system. Thus, UV-B may suppress local immunity against skin tumours and skin-associated infections as well as systemic immunity against non skin-associated infectious diseases and tumours.

Publication types

  • Review

MeSH terms

  • Animals
  • Humans
  • Immune Tolerance / radiation effects
  • Immunity / radiation effects*
  • Keratinocytes / radiation effects
  • Langerhans Cells / radiation effects
  • Mast Cells / radiation effects
  • Photoreceptor Cells / physiology
  • T-Lymphocytes / immunology
  • T-Lymphocytes / radiation effects*
  • Ultraviolet Rays*