Barrett's esophagus: an acquired condition with genetic predisposition

Am J Gastroenterol. 1993 Aug;88(8):1262-5.


We describe four families with a strong familial expression of Barrett's/gastroesophageal reflux disease (GERD) complex spanning one to four generations with two to seven affected members per family. The purpose of this report is to highlight genetic trends in Barrett's esophagus, stress the importance of a family history in gastroesophageal reflux disease, and to call attention to unique features of familial Barrett's esophagus.

Publication types

  • Case Reports

MeSH terms

  • Adenocarcinoma / genetics
  • Aged
  • Barrett Esophagus / genetics*
  • Barrett Esophagus / pathology
  • Biopsy
  • Esophageal Neoplasms / genetics
  • Esophagus / pathology
  • Female
  • Gastroesophageal Reflux / genetics*
  • Genes, Dominant
  • Humans
  • Male
  • Middle Aged
  • Pedigree