Prevalence of intestinal protozoans in French patients infected with HIV

J Acquir Immune Defic Syndr (1988). 1993 Sep;6(9):1024-9.

Abstract

To assess the prevalence of intestinal protozoans in French HIV-infected patients, stool samples, duodenojejunal biopsies, and/or colorectal biopsies from 81 patients were studied for parasites, viruses, and bacteria. Pathogens were found in 70.6% of AIDS patients with diarrhea or malabsorption. The respective prevalence of protozoa in AIDS patients with diarrhea was Cryptosporidium sp.: 37.3%, Blastocystis hominis: 13.7%, Giardia intestinalis: 5.8%, Isospora belli: 2%, Enterocytozoon bieneusi: 2%. Microsporidia were noted in one patient with severe malabsorption but no diarrhea. Other pathogens included cytomegalovirus in 27.4% and Mycobacterium avium in 5.8%. Patients with identified pathogens were more immunosuppressed and more severely malnourished than those with unexplained diarrhea. Multiple pathogens were found in 13 of 81 patients (16%). Twenty-six of 66 identified pathogens (40%) were diagnosed only on biopsy specimens. Chronic diarrhea in HIV patients could be explained in the vast majority by appropriate gastrointestinal investigations. Cryptosporidia played a major role, while microsporidia appeared to be less common.

MeSH terms

  • Acquired Immunodeficiency Syndrome / complications
  • Adult
  • Animals
  • Cohort Studies
  • Colon / parasitology
  • Colon / pathology
  • Cryptosporidiosis / complications
  • Cryptosporidiosis / epidemiology
  • Cryptosporidium / isolation & purification
  • Diarrhea / complications
  • Diarrhea / parasitology
  • Duodenum / parasitology
  • Duodenum / pathology
  • Endoscopy, Gastrointestinal
  • Eukaryota / isolation & purification
  • Feces / parasitology
  • Female
  • France / epidemiology
  • HIV Infections / complications*
  • Humans
  • Intestinal Diseases, Parasitic / complications
  • Intestinal Diseases, Parasitic / epidemiology*
  • Jejunum / parasitology
  • Jejunum / pathology
  • Malabsorption Syndromes / complications
  • Malabsorption Syndromes / parasitology
  • Male
  • Middle Aged
  • Prevalence
  • Prospective Studies
  • Protozoan Infections / complications
  • Protozoan Infections / epidemiology*
  • Rectum / parasitology
  • Rectum / pathology