Concanavalin A enhances ATP resynthesis via de novo pathway in postischemic rat hearts

Z T Tan; L Tan; X W Wang

doi:10.1016/0024-3205(93)90705-8

Concanavalin A enhances ATP resynthesis via de novo pathway in postischemic rat hearts

Life Sci. 1993;53(6):PL99-103. doi: 10.1016/0024-3205(93)90705-8.

Authors

Z T Tan¹, L Tan, X W Wang

Affiliation

¹ Department of Surgery, Colorado Health Sciences Center, Denver 80262.

PMID: 8341130
DOI: 10.1016/0024-3205(93)90705-8

Abstract

Acute post-ischemic cardiac failure was studied in isolated rat hearts. Xylitol, glutamine, aspartic acid and glycine were added during reperfusion, resulting in no inotropic effect. Concanavalin A had a moderate inotropic effect. When concanavalin A added with xylitol, glutamine, aspartic acid and glycine, a rapid recovery of myocardial function and high-energy phosphate was achieved.

MeSH terms

Adenosine Triphosphate / biosynthesis*
Animals
Aspartic Acid / pharmacology
Concanavalin A / pharmacology*
Drug Synergism
Glutamine / pharmacology
Glycine / pharmacology
In Vitro Techniques
Male
Myocardial Reperfusion Injury / metabolism*
Myocardial Reperfusion Injury / physiopathology
Rats
Rats, Wistar
Xylitol / pharmacology

Substances

Glutamine
Concanavalin A
Aspartic Acid
Adenosine Triphosphate
Glycine
Xylitol