Is gross proteinuria a risk factor for the incidence of proliferative diabetic retinopathy?

Ophthalmology. 1993 Aug;100(8):1140-6. doi: 10.1016/s0161-6420(93)31514-9.


Purpose: To examine the relationship between gross proteinuria, measured at the initial examination, and the 4-year incidence of proliferative diabetic retinopathy (PDR) in a population-based study in Wisconsin.

Methods: Gross proteinuria was measured by reagent strip. Diabetic retinopathy was determined from stereoscopic fundus photographs in a masked fashion using the modified Airlie House classification scheme.

Results: In the younger-onset group taking insulin (n = 693), the relative risk of proliferative retinopathy developing in those with gross proteinuria at baseline was 2.32 (95% confidence interval [CI]: 1.40,3.83) compared with those without gross proteinuria. For the older-onset group taking insulin, the relative risk was 2.02 (95% CI: 0.91,4.44), and for those not taking insulin it was 1.13 (95% CI: 0.15,8.50). After controlling for other risk variables, the relationship was of borderline statistical significance (P = 0.052) in the younger-onset group with no or early nonproliferative retinopathy at baseline.

Conclusion: These data suggest that gross proteinuria is a risk indicator for proliferative retinopathy in younger-onset patients with diabetes. These patients might benefit from having regular ophthalmologic evaluation.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adult
  • Age Factors
  • Diabetic Retinopathy / epidemiology
  • Diabetic Retinopathy / etiology*
  • Female
  • Humans
  • Incidence
  • Male
  • Odds Ratio
  • Proteinuria / complications*
  • Risk Factors
  • Wisconsin / epidemiology