Relatively few studies have been performed to examine the effectiveness of different methods of treatment for the inversion ankle sprain. In this study, restoration of function following a grade II inversion sprain was compared among 34 subjects who received one of three methods of treatment, each of which incorporated an Air-Stirrup brace. The methods included uniform compression provided by elastic tape, focal compression provided by a U-shaped device, and focal compression with simultaneous cryotherapy. Although the results failed to demonstrate statistical significance at the .05 level (p = .055), the two groups that received focal compression attained each of nine levels of function in fewer days than the group that received uniform compression. The results of this study indicate that focal compression appears beneficial, but increased frequency and duration of cryotherapy does not appear to enhance the rate of recovery following an inversion ankle sprain.