The chondroitin sulfate form of invariant chain can enhance stimulation of T cell responses through interaction with CD44

Cell. 1993 Jul 30;74(2):257-68. doi: 10.1016/0092-8674(93)90417-o.

Abstract

Invariant chain (Ii) is a nonpolymorphic glycoprotein that associates with major histocompatibility complex class II molecules and has been shown to mediate several functions in class II-restricted antigen presentation. A small proportion of Ii is modified by the addition of chondroitin sulfate (Ii-CS), and this form of Ii is associated with class II on the surface of antigen-presenting cells. In this report we show that expression of Ii-CS dramatically enhanced the ability of class II-positive EL4 transfectants to stimulate class II-dependent allogeneic and mitogenic T cell responses. Antibody blocking studies and the ability of CD44 to bind directly to Ii-CS suggest that Ii-CS can function as an accessory molecule during T cell responses through interactions with CD44.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Antigen-Presenting Cells / immunology*
  • Antigens, Differentiation, B-Lymphocyte*
  • Biological Transport
  • Cells, Cultured
  • Chondroitin Sulfates / immunology*
  • Glycoproteins / immunology
  • Glycoproteins / metabolism
  • Histocompatibility Antigens Class II / immunology*
  • Histocompatibility Antigens Class II / metabolism
  • Lymph Nodes / immunology
  • Lymphocyte Activation
  • Mesentery / immunology
  • Mice
  • Mice, Inbred C57BL
  • Protein Folding
  • Receptors, Lymphocyte Homing / immunology*
  • Receptors, Lymphocyte Homing / metabolism
  • T-Lymphocytes / immunology*

Substances

  • Antigens, Differentiation, B-Lymphocyte
  • Glycoproteins
  • Histocompatibility Antigens Class II
  • Receptors, Lymphocyte Homing
  • invariant chain
  • Chondroitin Sulfates