CD4+8- help prevents rapid deletion of CD8+ cells after a transient response to antigen

Eur J Immunol. 1993 Aug;23(8):1963-7. doi: 10.1002/eji.1830230835.


We have followed the fate of mature CD8+ T cells with a male-specific transgenic T cell receptor after antigenic stimulation with hemopoietic cells in the absence or presence of help. Our data show that mature CD8+ T cells can be deleted after a 3-week period of transient activation and that help, e.g. in the form of interleukin-2, can considerably delay the deletion. These experiments have implications for the design of protocols aiming at the establishment of specific immunological tolerance in T cells.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antigens / immunology*
  • CD4 Antigens / analysis*
  • CD8 Antigens / analysis*
  • Female
  • Immunization
  • Killer Cells, Natural / immunology*
  • Lymphocyte Activation
  • Male
  • Mice
  • Mice, Inbred BALB C
  • Mice, Inbred C57BL
  • Receptors, Antigen, T-Cell, alpha-beta / analysis
  • T-Lymphocytes, Helper-Inducer / immunology*


  • Antigens
  • CD4 Antigens
  • CD8 Antigens
  • Receptors, Antigen, T-Cell, alpha-beta