Differentiation of benign from malignant breast masses by time-intensity evaluation of contrast enhanced MRI

Magn Reson Imaging. 1993;11(5):617-20. doi: 10.1016/0730-725x(93)90002-u.


Using gadolinium-DTPA enhanced MRI we analyzed the enhancement characteristics of palpable breast masses in 23 patients--10 cancers and 13 benign lesions. The most specific finding for separating benign from malignant lesions was a ratio of maximum intensity change divided by the time interval during which this first occurred. Designated ranges of this ratio were specific for benign disease and sensitive for malignancy in this small patient group. Three of eight fibroadenomas exhibited enhancement patterns indistinguishable from cancer.

Publication types

  • Comparative Study

MeSH terms

  • Adenofibroma / diagnosis*
  • Adult
  • Aged
  • Breast Neoplasms / diagnosis*
  • Breast Neoplasms / pathology
  • Contrast Media*
  • Female
  • Fibrocystic Breast Disease / diagnosis*
  • Gadolinium
  • Gadolinium DTPA
  • Humans
  • Magnetic Resonance Imaging / methods*
  • Middle Aged
  • Organometallic Compounds*
  • Pentetic Acid*


  • Contrast Media
  • Organometallic Compounds
  • Pentetic Acid
  • Gadolinium
  • Gadolinium DTPA