Abstract
Different antigen-presenting cells elicit responses in different T-cell populations for primary activation, secondary stimulation and cytotoxic effector functions. Maturing bone marrow derived dendritic cells may acquire and process antigens, transport them to lymph nodes and activate naive T cells located there. By contrast, follicular dendritic cells, acquiring antigen-antibody complexes, maintain 'memory' via B-cell activation. Effector memory T cells recognize various tissue cells bearing antigen and we speculate that they may also target specialized antigen-presenting dendritic populations.
MeSH terms
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Animals
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Antigen-Presenting Cells* / immunology
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Antigens / immunology
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Antigens, CD / immunology
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Bone Marrow Cells
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Cell Movement
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Cytotoxicity, Immunologic
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Dendritic Cells / cytology
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Dendritic Cells / immunology
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HLA-D Antigens / immunology
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Histocompatibility Antigens Class I / immunology
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Humans
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Immunologic Memory / physiology
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Killer Cells, Natural / immunology
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Lymph Nodes / cytology
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Lymph Nodes / immunology
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Lymphocyte Activation
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Macrophages / immunology
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Mice
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Rats
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T-Lymphocytes, Cytotoxic / immunology
Substances
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Antigens
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Antigens, CD
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HLA-D Antigens
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Histocompatibility Antigens Class I