Sites of B-cell activation in vivo

Curr Opin Immunol. 1993 Jun;5(3):418-22. doi: 10.1016/0952-7915(93)90062-w.


Novel techniques have made possible in situ analyses of the lymphocyte populations responding to antigen. In the spleen, antigen-specific T and B cells are first observed in the periarteriolar lymphoid sheath. Following conjugate formation between specific T and B lymphocytes, B-cell proliferation and differentiation takes place in two distinct sites, the periarteriolar lymphoid sheath-associated foci and germinal centers.

Publication types

  • Review

MeSH terms

  • Animals
  • B-Lymphocyte Subsets / immunology*
  • Cell Division
  • Humans
  • Immunization
  • Lymphocyte Activation*
  • Lymphocyte Cooperation
  • Mice
  • Spleen / cytology
  • Spleen / immunology*
  • T-Lymphocytes / immunology