Giant basal cell carcinoma (T3). Who is at risk?

Cancer. 1993 Sep 1;72(5):1624-30. doi: 10.1002/1097-0142(19930901)72:5<1624::aid-cncr2820720522>;2-d.


Background: Giant basal cell carcinomas can cause extensive local invasion and disfigurement. This study determines in whom giant basal cell carcinomas develop.

Methods: Fifty patients with giant basal cell carcinomas (over 5 cm, T3) were compared with other groups of patients with small (< 2 cm, T1) or intermediate-sized (2-5 cm, T2) basal cell carcinomas. The patients were treated at the Mayo Clinic between August 1986 and December 1990.

Results: Characteristics that were more common in giant basal cell carcinomas than in smaller lesions were duration, patient neglect, recurrence after previous treatment, aggressive histologic pattern, and history of radiation exposure.

Conclusions: Patients who have a basal cell carcinoma with an aggressive histologic subtype, a recurrence after previous treatment, a history of radiation exposure, or a history of neglect are at risk for giant basal cell carcinoma.

MeSH terms

  • Adult
  • Age Factors
  • Aged
  • Aged, 80 and over
  • Ambulatory Surgical Procedures
  • Carcinoma, Basal Cell / pathology*
  • Carcinoma, Basal Cell / surgery
  • Educational Status
  • Electrocoagulation
  • Female
  • Head and Neck Neoplasms / pathology
  • Humans
  • Male
  • Mental Disorders / complications
  • Middle Aged
  • Mohs Surgery
  • Neoplasm Invasiveness
  • Neoplasm Recurrence, Local
  • Neoplasms, Radiation-Induced / pathology
  • Occupational Exposure
  • Retrospective Studies
  • Risk Factors
  • Sex Factors
  • Skin Neoplasms / pathology*
  • Skin Neoplasms / surgery
  • Skin Pigmentation
  • Time Factors