Transmission of mutans streptococci to infants following short term application of an iodine-NaF solution to mothers' dentition

Community Dent Oral Epidemiol. 1993 Jun;21(3):136-42. doi: 10.1111/j.1600-0528.1993.tb00738.x.


In a randomized clinical trial, six applications of an I2-NaF or a placebo solution were administered to the mothers' dentition at the time of tooth emergence of her infant, to evaluate its effect on transmission of mutans streptococci (MS) to the infant. MS and other bacterial levels were periodically monitored in 48 mother-infant pairs until the child's third birthday. There were significant reductions in maternal salivary MS (P = 0.04), lactobacilli (P = 0.04), total streptococci (P = 0.002), and total cultivable organisms (P = 0.004) immediately following treatment. In children, 3-yr incidence of MS colonization and the time of acquisition of MS or the caries experience did not differ significantly between the two groups. We conclude that short-term application of I2-NaF to the maternal dentition of predentate infants significantly lowers MS, lactobacilli, total streptococci, and total cultivable bacteria in mothers' saliva, but does not influence the incidence and the time of acquisition of MS or the caries experience in children.

Publication types

  • Clinical Trial
  • Randomized Controlled Trial
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adult
  • Child, Preschool
  • Colony Count, Microbial
  • Dental Caries / microbiology*
  • Dental Restoration, Permanent
  • Double-Blind Method
  • Drug Combinations
  • Female
  • Humans
  • Infant
  • Iodine / administration & dosage
  • Iodine / therapeutic use*
  • Lactobacillus / drug effects
  • Lactobacillus / isolation & purification
  • Male
  • Mother-Child Relations*
  • Placebos
  • Saliva / microbiology*
  • Sodium Fluoride / administration & dosage
  • Sodium Fluoride / therapeutic use*
  • Streptococcus / drug effects
  • Streptococcus / isolation & purification
  • Streptococcus mutans / drug effects
  • Streptococcus mutans / isolation & purification*
  • Streptococcus sanguis / drug effects
  • Streptococcus sanguis / isolation & purification


  • Drug Combinations
  • Placebos
  • Sodium Fluoride
  • Iodine