Molecular characterization of a mouse Y chromosomal repetitive sequence amplified in distantly related species in the genus Mus

Genome. 1993 Jun;36(3):588-93. doi: 10.1139/g93-079.


This report describes a 1.1 kb long mouse Y chromosomal sequence designated 142-4. It has a 42% GC content and is rich in short direct and inverted repeats. 142-4 related sequences are repeated about 200 times in the Mus musculus Y chromosome and their distribution was visualized by in situ hybridization. 142-4 detected a restriction fragment length polymorphism that differentiated between the M. m. musculus type and the M. m. domesticus type Y chromosome. Southern blot analysis of DNAs isolated from a panel of mouse species showed that 142-4 related sequences were amplified in the Y chromosomes of M. minutoides, M. musculus, M. saxicola, M. spicilegus, and M. spretus but not in those of M. caroli, M. cookii, and M. pahari. These results suggest that 142-4 related sequences are evolutionarily unstable and their accumulation patterns do not correlate with the known phylogenetic relationships of mouse species in the genus Mus.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Base Sequence
  • Biological Evolution
  • DNA / genetics
  • Female
  • Gene Amplification
  • In Situ Hybridization, Fluorescence
  • Male
  • Mice
  • Mice, Inbred BALB C
  • Mice, Inbred C57BL
  • Molecular Sequence Data
  • Muridae / genetics*
  • Polymorphism, Genetic
  • Repetitive Sequences, Nucleic Acid*
  • Species Specificity
  • Y Chromosome*


  • DNA

Associated data

  • GENBANK/L20583
  • GENBANK/L20584
  • GENBANK/M76736
  • GENBANK/X64425
  • GENBANK/X64426
  • GENBANK/X64427
  • GENBANK/X64428
  • GENBANK/X68165
  • GENBANK/X68166
  • GENBANK/Z22861