Effects of testosterone on the development of endometrial tumors in female rats

Gynecol Obstet Invest. 1993;36(1):29-33. doi: 10.1159/000292589.

Abstract

Long-term treatment of mature virgin female rats with a high dose of testosterone (24 weeks at a total dose of 300 mg) was associated with the development of endometrial adenomatous hyperplasia and resulted in a high incidence of adenocarcinoma when administered in combination with 7,12-dimethyl-benz[a]anthracene (DMBA; 2 mg in 0.1 ml sesame oil) introduced into the uterine cavity. Adenomatous hyperplasia occurred in all testosterone-treated rats, both with and without ovaries. Testosterone may promote the induction of endometrial tumors by DMBA.

MeSH terms

  • 9,10-Dimethyl-1,2-benzanthracene*
  • Adenocarcinoma / chemically induced*
  • Adenocarcinoma / pathology
  • Animals
  • Endometrial Hyperplasia / chemically induced*
  • Endometrial Hyperplasia / pathology
  • Endometrial Neoplasms / chemically induced*
  • Endometrial Neoplasms / pathology
  • Endometrium / pathology
  • Female
  • Rats
  • Rats, Wistar
  • Testosterone / administration & dosage
  • Testosterone / pharmacology*
  • Time Factors

Substances

  • Testosterone
  • 9,10-Dimethyl-1,2-benzanthracene