Low dose leucovorin does not interfere with the efficacy of methotrexate in rheumatoid arthritis: an 8 week randomized placebo controlled trial

J Rheumatol. 1993 Jun;20(6):950-2.


Objective: To determine if simultaneously administered low dose leucovorin interferes with the efficacy of methotrexate (MTX).

Methods: An 8-week double blind placebo controlled study of leucovorin (1 mg) in 16 patients with rheumatoid arthritis receiving chronic MTX was performed at a single academic center.

Results: A flare of disease activity was not observed. Clinical variables of arthritis activity did not change in the leucovorin treated population.

Conclusions: Low dose leucovorin when taken simultaneously with MTX did not interfere with the efficacy of MTX in a short term 8 week trial.

Publication types

  • Clinical Trial
  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Arthritis, Rheumatoid / drug therapy*
  • Double-Blind Method
  • Drug Therapy, Combination
  • Female
  • Humans
  • Leucovorin / administration & dosage*
  • Leucovorin / adverse effects
  • Male
  • Methotrexate / administration & dosage*
  • Methotrexate / adverse effects
  • Methotrexate / antagonists & inhibitors
  • Middle Aged


  • Leucovorin
  • Methotrexate