Objective: To determine if simultaneously administered low dose leucovorin interferes with the efficacy of methotrexate (MTX).
Methods: An 8-week double blind placebo controlled study of leucovorin (1 mg) in 16 patients with rheumatoid arthritis receiving chronic MTX was performed at a single academic center.
Results: A flare of disease activity was not observed. Clinical variables of arthritis activity did not change in the leucovorin treated population.
Conclusions: Low dose leucovorin when taken simultaneously with MTX did not interfere with the efficacy of MTX in a short term 8 week trial.