Hydantoin syndrome with holoprosencephaly: a possible rare teratogenic effect

Teratology. 1993 Jul;48(1):15-9. doi: 10.1002/tera.1420480105.


We report on a newborn girl with lobar holoprosencephaly and clinical signs of hydantoin syndrome. During pregnancy the mother was treated with diphenylhydantoin and primidon for psychomotor and petit mal seizures. The possible relationship between hydantoin syndrome, holoprosencephaly, and maternal intake of anticonvulsants during pregnancy is discussed.

Publication types

  • Case Reports

MeSH terms

  • Abnormalities, Drug-Induced*
  • Female
  • Holoprosencephaly / chemically induced*
  • Holoprosencephaly / diagnostic imaging
  • Humans
  • Infant, Newborn
  • Magnetic Resonance Imaging
  • Phenytoin / adverse effects*
  • Radiography
  • Syndrome


  • Phenytoin