The hypotriglyceridemic effect of fish oil in adult-onset diabetes without adverse glucose control

Ann N Y Acad Sci. 1993 Jun 14;683:337-40. doi: 10.1111/j.1749-6632.1993.tb35725.x.

Abstract

Diabetic control as judged by five criteria did not deteriorate after 6 months of fish oil compared to 6 months of olive oil supplementation in 16 patients with NIDDM who were eating a low fat, high complex carbohydrate diet. Plasma total and VLDL triglyceride and cholesterol decreased significantly after fish oil supplementation; plasma total and HDL cholesterol concentrations did not change. The LDL cholesterol level was significantly increased with fish oil supplementation, suggesting that patients with NIDDM who are given a fish oil supplement to decrease the plasma total and VLDL triglyceride levels may also need further dietary and/or pharmaceutical therapy to maintain an LDL cholesterol level compatible with a low risk of coronary disease. The study emphasizes the safe use of fish oil over a 6-month period in diabetic patients.

Publication types

  • Clinical Trial
  • Randomized Controlled Trial
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Aged
  • Blood Glucose / metabolism*
  • Cholesterol / blood
  • Cholesterol, LDL / blood
  • Diabetes Mellitus, Type 2 / blood*
  • Dietary Fats, Unsaturated / administration & dosage
  • Dietary Fats, Unsaturated / pharmacology*
  • Double-Blind Method
  • Female
  • Fish Oils / administration & dosage
  • Fish Oils / pharmacology*
  • Humans
  • Lipoproteins, VLDL / blood
  • Male
  • Middle Aged
  • Placebos
  • Triglycerides / blood*

Substances

  • Blood Glucose
  • Cholesterol, LDL
  • Dietary Fats, Unsaturated
  • Fish Oils
  • Lipoproteins, VLDL
  • Placebos
  • Triglycerides
  • Cholesterol