A metastatic orthotopic-transplant nude-mouse model of human patient breast cancer

Anticancer Res. Jul-Aug 1993;13(4):901-4.


We report here the development of an orthotopic-transplant model of human patient breast cancer in nude mice. Histologically-intact patient breast tumor tissue was transplanted as intact tissue to the mammary fat pad of nude mice where the tumor tissue grew extensively and metastasized to the lung. This is the first orthotopic-transplant metastatic model of human breast cancer. The potential clinical and basic-science uses of the model are discussed.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Breast Neoplasms / genetics
  • Breast Neoplasms / pathology*
  • DNA Probes
  • Female
  • Humans
  • In Situ Hybridization
  • Lung Neoplasms / genetics
  • Lung Neoplasms / pathology
  • Lung Neoplasms / secondary*
  • Mice
  • Mice, Nude
  • Neoplasm Metastasis
  • Neoplasm Transplantation / methods
  • Transplantation, Heterologous / methods


  • DNA Probes