Regulation of the NF-kappa B/rel transcription factor and I kappa B inhibitor system

Curr Opin Cell Biol. 1993 Jun;5(3):477-87. doi: 10.1016/0955-0674(93)90014-h.


The interplay between proteins of the NF-kappa B/rel and I kappa B families is a tightly regulated process that ensures appropriate responses to specific environmental and developmental signals. Various mechanisms are utilized in regulating NF-kappa B/rel and I kappa B activities, some unique to this transcription factor system. All of these regulatory strategies converge towards one purpose, namely the controlled nuclear translocation of activated NF-kappa B/rel protein complexes. The variety of rel-related and ankyrin repeat containing subunits makes regulation of this system both rich and complicated.

Publication types

  • Review

MeSH terms

  • Animals
  • Base Sequence
  • DNA
  • Gene Expression Regulation
  • Humans
  • Molecular Sequence Data
  • NF-kappa B / genetics
  • NF-kappa B / metabolism*
  • Proto-Oncogene Proteins / genetics
  • Proto-Oncogene Proteins / metabolism*
  • Transcription Factor RelB
  • Transcription Factors*
  • Transcription, Genetic*


  • NF-kappa B
  • Proto-Oncogene Proteins
  • RELB protein, human
  • Transcription Factors
  • Transcription Factor RelB
  • DNA