Genetic control of gastrulation in the mouse

Curr Opin Genet Dev. 1993 Jun;3(3):491-8. doi: 10.1016/0959-437x(93)90125-9.


In the past, understanding of the process of gastrulation in the mouse has primarily been based on morphological analyses. Recently, a number of molecules have been implicated in mesoderm induction and axis formation in Xenopus, and several of these exhibit unique patterns of expression during mouse gastrulation. These gene-expression data, together with fate mapping, ectopic expression experiments and mutational analysis, will now facilitate studies on the functional aspects of gastrulation in the mouse.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Embryonic and Fetal Development / genetics*
  • Gastrula*
  • Mice