Gene therapy: adenovirus vectors

Curr Opin Genet Dev. 1993 Jun;3(3):499-503. doi: 10.1016/0959-437x(93)90126-a.


The past year has seen a proliferation in the use of recombinant, replication-defective adenoviruses for experimental models of gene therapy. The fact that adenovirus infects most cell types with no requirement for cell division, combined with the high titers and high efficiency of gene transfer obtainable with recombinant adenovirus, make it a promising system for in vivo human gene therapy.

Publication types

  • Review

MeSH terms

  • Adenoviruses, Human / genetics*
  • Animals
  • Genetic Therapy / methods*
  • Genetic Vectors*
  • Humans