Effect of antimicrobial treatment on chronic reactive arthritis

Clin Exp Rheumatol. 1993 May-Jun;11(3):301-7.


In a double-blind study comprising 36 patients the effect of a three-month course of ciprofloxacin on chronic reactive arthritis was evaluated. At the end of the follow-up period 6 months after stopping the therapy, arthralgia, pain at movement and morning stiffness had decreased significantly compared to the values before the treatment in the ciprofloxacin group, whereas the Ritchie index and ESR showed a significant decrease in the control group. We conclude that further studies are necessary before the value of prolonged ciprofloxacin treatment of chronic reactive arthritis can be established.

Publication types

  • Clinical Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Anti-Bacterial Agents / therapeutic use*
  • Arthritis, Reactive / drug therapy*
  • Arthritis, Reactive / physiopathology
  • Blood Sedimentation
  • Campylobacter Infections / drug therapy*
  • Campylobacter jejuni
  • Chronic Disease
  • Ciprofloxacin / therapeutic use*
  • Double-Blind Method
  • Female
  • Humans
  • Male
  • Middle Aged
  • Severity of Illness Index
  • Yersinia Infections / drug therapy*
  • Yersinia Infections / physiopathology


  • Anti-Bacterial Agents
  • Ciprofloxacin