[Infection and systemic lupus erythematosus: analysis of a series of 145 patients]

Rev Clin Esp. 1993 Jul;193(3):105-9.
[Article in Spanish]


Systemic lupus erythematosus (SEL) is a chronic inflammatory disease, which often requires corticosteroid treatment, being infection a common cause of both morbidity and mortality. We report the infectious episodes from 145 SLE patients revisited through 1975-1991, with a 6.8 years mean follow-up period. The relationship between each episode and several variables, especially corticosteroid treatment a month before the infectious episode, was analyzed. Forty two infections were diagnosed in 32 patients (22.06%). A significant increase in the number of infections among SLE patients with daily corticosteroids treatment was observed with respect to that of SLE patients with alternate day treatment (p < 0.001). The administration corticosteroids in alternate day form, if possible, can decrease the infection incidence in SLE patients.

Publication types

  • English Abstract

MeSH terms

  • Adolescent
  • Adrenal Cortex Hormones / administration & dosage*
  • Adrenal Cortex Hormones / therapeutic use
  • Adult
  • Aged
  • Bacterial Infections / epidemiology
  • Bacterial Infections / etiology
  • Bacterial Infections / prevention & control*
  • Child
  • Drug Administration Schedule
  • Female
  • Follow-Up Studies
  • Humans
  • Lupus Erythematosus, Systemic / complications*
  • Male
  • Middle Aged
  • Opportunistic Infections / epidemiology
  • Opportunistic Infections / etiology
  • Opportunistic Infections / prevention & control*
  • Retrospective Studies


  • Adrenal Cortex Hormones