Outcome at ages 1, 3, and 5 years of children born to diabetic women

Am J Obstet Gynecol. 1977 Feb 15;127(4):408-13. doi: 10.1016/0002-9378(77)90499-9.


A prospective study of infants born to women with diabetes mellitus is reported. The children were examined at birth and followed at 1, 3, and 5 years of age. Medical and psychological information was obtained through follow-up examinations. Intrauterine growth was atypical and there was an increase in neonatal problems and congenital malformations. There was an increased incidence of intellectual delay at 3 and 5 years of age. The presence of acetone in the urine during pregnancy had a significant, adverse effect on intellectual status of the offspring at 5 years of age. Birth weight was negatively related to intellectual status at both 3 and 5 years of age.

MeSH terms

  • Acetone / urine
  • Age Factors
  • Child, Preschool
  • Congenital Abnormalities / epidemiology
  • Congenital Abnormalities / etiology
  • Female
  • Follow-Up Studies
  • Humans
  • Infant
  • Infant, Newborn
  • Infant, Newborn, Diseases / epidemiology
  • Infant, Newborn, Diseases / etiology
  • Infant, Small for Gestational Age
  • Intellectual Disability / epidemiology
  • Intellectual Disability / etiology
  • Iowa
  • Pregnancy
  • Pregnancy in Diabetics* / complications
  • Prospective Studies


  • Acetone