Abstract
The reaction product against rat Isk protein antibody was demonstrated on the endolymphatic surface of the marginal cell of the guinea pig, using an immunohistochemical method. Clofilium, a potassium channel blocker which has been previously found to block rat kidney Isk channels, decreased the endocochlear potential (EP) when applied by perilymphatic perfusion and iontophoresis into endolymph. This finding of a decreased EP supports the presence of Isk protein on the endolymphatic surface of the marginal cell.
MeSH terms
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Action Potentials
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Animals
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Electrophysiology
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Guinea Pigs
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Immunohistochemistry
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Iontophoresis
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Membrane Proteins / metabolism*
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Potassium Channels / metabolism*
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Potassium Channels, Voltage-Gated*
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Quaternary Ammonium Compounds / pharmacology
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Stria Vascularis / cytology
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Stria Vascularis / drug effects
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Stria Vascularis / metabolism*
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Stria Vascularis / physiology*
Substances
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Membrane Proteins
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Potassium Channels
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Potassium Channels, Voltage-Gated
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Quaternary Ammonium Compounds
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potassium channel protein I(sk)
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clofilium