Birth asphyxia and the neonatal brain: what do we know and when do we know it?

Clin Perinatol. 1993 Jun;20(2):327-44.


In this article, the authors examine whether indicators commonly used to recognized birth asphyxia are specific to asphyxial states, and whether these allow recognition of a severity of asphyxia sufficient to pose a risk of irreversible brain injury. Characteristics recognizable within the first hours after birth are focused on because these characteristics will be of most use in clinical decisions regarding use of potential new therapies for asphyxia.

Publication types

  • Review

MeSH terms

  • Amniotic Fluid
  • Apgar Score
  • Asphyxia Neonatorum / complications
  • Asphyxia Neonatorum / diagnosis*
  • Asphyxia Neonatorum / epidemiology
  • Asphyxia Neonatorum / physiopathology
  • Asphyxia Neonatorum / therapy
  • Biomarkers
  • Blood Gas Analysis
  • Brain Diseases / epidemiology
  • Brain Diseases / etiology
  • Causality
  • Cerebral Palsy / epidemiology
  • Cerebral Palsy / etiology
  • Decision Making
  • Female
  • Heart Rate, Fetal
  • Humans
  • Infant, Newborn
  • Meconium
  • Predictive Value of Tests
  • Pregnancy
  • Pulmonary Gas Exchange
  • Severity of Illness Index


  • Biomarkers