Agr-related sequences in Staphylococcus lugdunensis

FEMS Microbiol Lett. 1993 Jul 15;111(1):115-22. doi: 10.1111/j.1574-6968.1993.tb06370.x.


Sequences related to the Staphylococcus aureus accessory gene regulator (agr) were demonstrated in S. lugdunensis by Southern blot analysis of 13 strains and sequencing of the S. lugdunensis agr-like locus (agr-sl). Northern blot analysis of cellular RNA revealed the presence of a transcript having homology with the agr-P3 transcript (RNAIII) for three of the six strains tested. The three strains containing this transcript produce a hemolysin with phenotypic properties similar to that of S. aureus delta-hemolysin. Nevertheless, unlike agr-P3 from S. aureus, agr-sl does not encode any potential peptide homologous to S. aureus delta-hemolysin, suggesting that the hemolytic activity detected in S. lugdunensis is encoded elsewhere and may be controlled by agr-sl.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Amino Acid Sequence
  • Bacterial Proteins / genetics
  • Base Sequence
  • Blotting, Southern
  • Cloning, Molecular
  • DNA / genetics
  • DNA / isolation & purification
  • Genes, Bacterial*
  • Genes, Regulator*
  • Hemolysin Proteins
  • Humans
  • Molecular Sequence Data
  • Restriction Mapping
  • Sequence Homology, Amino Acid
  • Sequence Homology, Nucleic Acid
  • Species Specificity
  • Staphylococcus / genetics*
  • Staphylococcus / isolation & purification
  • Staphylococcus aureus / genetics
  • Transcription, Genetic


  • Bacterial Proteins
  • Hemolysin Proteins
  • delta hemolysin protein, Staphylococcus aureus
  • DNA

Associated data

  • GENBANK/L13334