Reproducibility of resting cerebral blood flow measurements with H2(15)O positron emission tomography in humans

J Cereb Blood Flow Metab. 1993 Sep;13(5):748-54. doi: 10.1038/jcbfm.1993.95.


Two consecutive measurements of resting CBF were carried out in normal volunteers (n = 25) using H2(15)O positron emission tomography. Absolute whole-brain blood flow (WBBF; ml 100 g-1 min-1, mean +/- SD) for the first (40.3 +/- 6.4) and second (39.3 +/- 6.5) measurements was not significantly different (mean % difference 2.3 +/- 8.7). Analysis of regions of interest showed no significant differences in absolute regional CBF (rCBF) and normalized (rCBF/WBBF) rCBF. Left-right differences were also not significant. These data demonstrate the reproducibility of resting CBF measurements in normal humans.

MeSH terms

  • Adult
  • Affect
  • Cerebrovascular Circulation*
  • Humans
  • Male
  • Mental Status Schedule
  • Oxygen Radioisotopes
  • Reference Values
  • Regional Blood Flow
  • Reproducibility of Results
  • Rest
  • Tomography, Emission-Computed*
  • Water*


  • Oxygen Radioisotopes
  • Water