Striatal 18F-dopa uptake: absence of an aging effect

J Cereb Blood Flow Metab. 1993 Sep;13(5):881-8. doi: 10.1038/jcbfm.1993.110.


L-[18F]6-Fluoro-DOPA (L-[18F]6-fluoro-3,4-dihydroxyphenylalanine; FDOPA) has been used with quantitative positron emission tomography (PET) to assess presynaptic nigrostriatal dopaminergic function in life. The relationship of estimated kinetic rate constants for striatal FDOPA uptake [Ki(FDOPA)] to the normal aging process has been the subject of conflicting reports. Resolution of this issue has been hampered by methodological differences in previous FDOPA/PET investigations. We studied 19 healthy normal subjects (aged 27-77 years) and measured striatal Ki-(FDOPA) according to each of the earlier methods. While significant correlations (p < 0.005) existed between Ki(FDOPA) values estimated by the various techniques, none correlated with normal aging. We conclude that normal striatal Ki(FDOPA) values estimated using quantitative FDOPA/PET are uncorrelated with the aging process.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Aging / metabolism*
  • Corpus Striatum / diagnostic imaging
  • Corpus Striatum / metabolism*
  • Dihydroxyphenylalanine / analogs & derivatives*
  • Dihydroxyphenylalanine / blood
  • Dihydroxyphenylalanine / pharmacokinetics
  • Dihydroxyphenylalanine / pharmacology
  • Female
  • Fluorine Radioisotopes
  • Humans
  • Male
  • Middle Aged
  • Reference Values
  • Tomography, Emission-Computed


  • Fluorine Radioisotopes
  • 3-O-methyl-6-fluoro-dopa
  • fluorodopa F 18
  • Dihydroxyphenylalanine