Abstract
The relative efficacy of a single 400 mg dose of albendazole or mebendazole in the treatment of nematode infections was assessed in 2- to 9-year-old children living in two different Bolivian rural communities. Both agents were equally very effective (100% cure rate) in treating ascariasis. Albendazole was clearly more active than mebendazole against hookworm infections, both in terms of egg reduction rate (92.8% vs. 62.4%) and cure rate (81.8% vs. 17.2%). As far as trichuriasis is concerned, albendazole produced a higher egg reduction rate than mebendazole (45.7% vs 15%), but a lower cure rate (33.3% vs 60%). Both drugs were well tolerated.
Publication types
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Clinical Trial
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Comparative Study
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Randomized Controlled Trial
MeSH terms
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Age Factors
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Albendazole / administration & dosage*
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Albendazole / therapeutic use
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Analysis of Variance
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Animals
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Ascariasis / complications
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Ascariasis / drug therapy*
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Ascariasis / epidemiology
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Ascariasis / parasitology
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Ascaris lumbricoides*
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Bolivia / epidemiology
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Child
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Child, Preschool
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Feces / parasitology
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Hookworm Infections / complications
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Hookworm Infections / drug therapy*
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Hookworm Infections / epidemiology
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Hookworm Infections / parasitology
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Humans
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Mebendazole / administration & dosage*
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Mebendazole / therapeutic use
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Parasite Egg Count
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Prevalence
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Rural Population
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Treatment Outcome
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Trichuriasis / complications
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Trichuriasis / drug therapy*
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Trichuriasis / epidemiology
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Trichuriasis / parasitology