A spontaneous mutation characterized by chronic proliferative dermatitis in C57BL mice

Am J Pathol. 1993 Sep;143(3):972-82.

Abstract

Chronic proliferative dermatitis is a new spontaneous mutation in C57BL/Ka mice. Breeding results suggest an autosomal recessive mode of inheritance. Mutant mice develop skin lesions at the age of 5 to 6 weeks. The lesions occur in the ventral and dorsal skin of the body, whereas ears, footpads, and tail are not involved. The lesions are characterized by epidermal hyperplasia, hyper- and parakeratosis, and single cell necrosis of keratinocytes. The dermis and epidermis are infiltrated by granulocytes and macrophages, and occasionally subcorneal and intracorneal microabscesses are formed. The number of mast cells in the dermis progressively increases with age. There is dilatation and proliferation of dermal capillaries. Similar lesions develop in the mouth, esophagus, and forestomach, which, in the mouse, are all lined by orthokeratinizing stratified squamous cell epithelium. Studies with bromodeoxyuridine confirm the increased rate of epithelial cell proliferation. Most inflammatory cells in the affected skin express Mac-1, and few express the T lymphocyte marker CD3. There is increased expression of intracellular adhesion molecule-1 on keratinocytes and endothelial cells. Infiltration of neutrophils and macrophages are also seen in the liver, lung, and several joints. The disease could not be transferred by bone marrow or spleen transplants into irradiated normal syngeneic hosts. Treatment of the mice with triamcinolone, a long-acting corticosteroid, resulted in nearly complete regression of the lesions over a period of 4 weeks, whereas systemic cyclosporin A treatment was ineffective.

MeSH terms

  • Adrenal Cortex Hormones / therapeutic use
  • Animals
  • Chronic Disease
  • Cyclosporine / therapeutic use
  • Dermatitis / drug therapy
  • Dermatitis / genetics
  • Dermatitis / pathology
  • Dermatitis / veterinary*
  • Disease Models, Animal
  • Immunohistochemistry
  • Mast Cells / pathology
  • Mice
  • Mice, Inbred C57BL
  • Mutation
  • Rodent Diseases / drug therapy
  • Rodent Diseases / genetics
  • Rodent Diseases / pathology*
  • Skin / drug effects
  • Skin / pathology

Substances

  • Adrenal Cortex Hormones
  • Cyclosporine