Central serous chorioretinopathy in endogenous hypercortisolism

Arch Ophthalmol. 1993 Sep;111(9):1229-33. doi: 10.1001/archopht.1993.01090090081024.


Objective: To examine the potential association of central serous chorioretinopathy with endogenous hypercortisolism (Cushing's syndrome).

Design: Ophthalmologic survey of consecutively admitted patients with endogenous Cushing's syndrome.

Setting: An eye clinic of a research center (National Eye Institute, Bethesda, Md).

Patients: Sixty consecutive patients with confirmed endogenous Cushing's syndrome.

Main outcome measures: Findings from complete ophthalmologic evaluation.

Results: Three (5%) of 60 patients had one or more episodes of appropriately documented central serous chorioretinopathy. In all cases, the episodes occurred during the period of hypercortisolism.

Conclusions: Central serous chorioretinopathy is an uncommon manifestation of endogenous Cushing's syndrome. Since central serous chorioretinopathy has been associated with other hypercortisolemic states, we suggest that glucocorticoids may play a role in the development of this disease.

Publication types

  • Case Reports

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Child
  • Choroid Diseases / complications*
  • Choroid Diseases / etiology
  • Cushing Syndrome / complications*
  • Exudates and Transudates
  • Female
  • Fluorescein Angiography
  • Fundus Oculi
  • Glucocorticoids / physiology
  • Humans
  • Male
  • Middle Aged
  • Retinal Detachment / diagnosis
  • Retinal Detachment / urine
  • Retinal Diseases / complications*
  • Retinal Diseases / etiology


  • Glucocorticoids