Activation-induced cell death (apoptosis) of mature peripheral T lymphocytes

Immunol Today. 1993 Jul;14(7):338-9. doi: 10.1016/0167-5699(93)90231-9.


Programmed cell death (apoptosis) is triggered in immature thymocytes and T-cell hybridomas by signalling via the CD3-T-cell receptor pathway. In this paper, Dieter Kabelitz and colleagues catalogue the recently accumulating evidence that apoptosis can also be initiated in mature peripheral T cells; this may constitute an important aspect of cellular immune regulation.

Publication types

  • Review

MeSH terms

  • Allergy and Immunology / trends
  • Animals
  • Apoptosis / immunology*
  • CD3 Complex
  • Cell Differentiation
  • Humans
  • In Vitro Techniques
  • Lymphocyte Activation
  • Receptors, Antigen, T-Cell
  • T-Lymphocytes / cytology
  • T-Lymphocytes / immunology*


  • CD3 Complex
  • Receptors, Antigen, T-Cell