Antigen presentation, loss of immunological memory and AIDS

Immunol Today. 1993 Jul;14(7):340-4. doi: 10.1016/0167-5699(93)90232-A.


A key factor causing immunodeficiency in HIV infection seems to be defective antigen presentation. Consequently, CD4+ T-cell populations, initially those expressing CD45RO, decrease in number not because of their destruction, but because they fail to expand in response to antigenic stimulation. This view implies that it would be mistaken to aim therapies only at correcting T-cell function or preventing infection of T cells.

Publication types

  • Review

MeSH terms

  • Acquired Immunodeficiency Syndrome / immunology*
  • Antigen-Presenting Cells / immunology
  • Humans
  • Immunologic Memory
  • Leukocyte Common Antigens
  • Lymphocyte Activation
  • Phenotype
  • T-Lymphocyte Subsets / immunology


  • Leukocyte Common Antigens