Review
doi: 10.1016/0167-5699(93)90235-D.
Bidirectional cytokine interactions in the maternal-fetal relationship: is successful pregnancy a TH2 phenomenon?
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- PMID: 8363725
- DOI: 10.1016/0167-5699(93)90235-D
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Review
Bidirectional cytokine interactions in the maternal-fetal relationship: is successful pregnancy a TH2 phenomenon?
Immunol Today.
1993 Jul.
Abstract
Pregnant females are susceptible to intracellular pathogens and are biased towards humoral rather than cell-mediated immunity. Since TH1 cytokines compromise pregnancy and TH2 cytokines are produced at the maternal-fetal interface, we hypothesize that these TH2 cytokines inhibit TH1 responses, improving fetal survival but impairing responses against some pathogens.
Comment in
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Cytokines and the maternal-fetal interface.Immunol Today. 1994 Jun;15(6):295. doi: 10.1016/0167-5699(94)90010-8. Immunol Today. 1994. PMID: 8068176 No abstract available.
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