Malignant lymphoma of bladder. Report of three cases and review of the literature

Cancer. 1993 Sep 15;72(6):1969-74. doi: 10.1002/1097-0142(19930915)72:6<1969::aid-cncr2820720630>;2-a.


Background: The significance of long-standing cystitis has been postulated as a causal factor in malignant lymphoma of bladder.

Methods: The authors reviewed 3 cases of primary malignant lymphoma of the urinary bladder and an additional 27 cases described in the literature (25 from Western countries and 2 from Japan). Clinical and pathologic findings in the total 30 cases are summarized.

Results: The majority of patients presented with gross hematuria and were between 20 and 85 years of age (median age, 64 years). Marked female preponderance was found (male to female ratio, 1:6.5). Six patients (20%), all of whom were women, out of 30 had a history of chronic cystitis. Macroscopic findings showed a solitary mass (22 cases), multiple masses (6 cases), or a diffuse lesion without nodule formation (2 cases). The vast majority of bladder lymphoma were non-Hodgkin lymphoma (NHL) of B-cell type; among them, 14% were follicular lymphomas. Follow-up indicated that NHL of bladder had a favorable prognosis.

Conclusions: Malignant lymphoma of bladder is characterized by a preponderance in women, who are occasionally affected by chronic cystitis.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Adult
  • Aged
  • B-Lymphocytes / pathology
  • Cystitis / complications
  • Female
  • Humans
  • Immunohistochemistry
  • Lymphoma, Non-Hodgkin / pathology*
  • Male
  • Middle Aged
  • Urinary Bladder Neoplasms / pathology*