Localized Wegener's granulomatosis relapsing as diffuse massive intra-alveolar hemorrhage

Chest. 1993 Sep;104(3):955-6. doi: 10.1378/chest.104.3.955.


In a 75-year-old patient presenting with a solitary pulmonary mass, a localized form of Wegener's granulomatosis was diagnosed after lobectomy. In the absence of extrapulmonary manifestations and after a benign postoperative course, the patients was discharged without medical treatment. Three months later, diffuse alveolar hemorrhage developed abruptly, necessitating mechanical ventilation, and was followed by cardiac complications and a fatal outcome. This case and another previously reported strongly suggest the need for medical treatment in patients with a localized form of pulmonary Wegener's granulomatosis, even when complete remission after surgical resection of the lung lesion seems to have been achieved.

Publication types

  • Case Reports

MeSH terms

  • Aged
  • Female
  • Granulomatosis with Polyangiitis / complications*
  • Granulomatosis with Polyangiitis / surgery
  • Hemorrhage / etiology*
  • Humans
  • Lung Diseases / complications*
  • Lung Diseases / surgery
  • Pneumonectomy
  • Recurrence