Thionyl-chloride-induced lung injury and bronchiolitis obliterans

Chest. 1993 Sep;104(3):971-3. doi: 10.1378/chest.104.3.971.


Thionyl-chloride (TCl) is used in the manufacture of lithium batteries, producing SO2 and HCl fumes on contact with water. We report two cases of accidental TCl exposure resulting in lung injury that may vary from a relatively mild and reversible interstitial lung disease to a severe form of bronchiolitis obliterans causing, after a latent period, an acute/chronic respiratory failure as well as other complications (spontaneous pneumothorax and bronchopleural fistula), previously unreported in TCl fume inhalation.

Publication types

  • Case Reports

MeSH terms

  • Accidents, Occupational
  • Adult
  • Bronchiolitis Obliterans / chemically induced
  • Bronchiolitis Obliterans / diagnostic imaging
  • Forced Expiratory Volume
  • Humans
  • Lung Diseases / chemically induced*
  • Lung Diseases / diagnostic imaging
  • Male
  • Radiography
  • Sulfur Oxides / adverse effects*
  • Vital Capacity


  • Sulfur Oxides
  • thionyl chloride