A comparison of propofol with other injectable anaesthetics in a rat model for measuring cardiovascular parameters

Lab Anim. 1993 Jul;27(3):250-7. doi: 10.1258/002367793780745354.


Prolonged, stable, non-recovery anaesthesia is required for the assessment of the effects of novel compounds on the cardiovascular system. A comparison of injectable anaesthetic agents and combinations (thiobarbital, fentanyl-fluanisone and midazolam, propofol, fentanyl-fluanisone and propofol, and alphaxalone/alphadolone) was made in laboratory rats and the following parameters assessed over 3 h: blood pressure, heart rate and rhythm, respiration rate and depth, analgesia, ease of induction and maintenance of anaesthesia. It was found that propofol, with fentanyl-fluanisone premedication, provided stress-free induction, easily controlled anaesthesia, good analgesia and muscle relaxation for surgery, for up to 3 h duration. Heart rate, blood pressure and respiration remained stable and within normal limits during this time. The other anaesthetics/combinations assessed did not rate as highly in these respects. Propofol, following fentanyl-fluanisone premedication, would appear to be a useful and safe anaesthetic for use in rodents, which avoids significant effects on heart rate or blood pressure.

Publication types

  • Comparative Study

MeSH terms

  • Anesthesia, Intravenous / veterinary*
  • Anesthetics / pharmacology*
  • Animals
  • Blood Pressure / drug effects*
  • Butyrophenones / pharmacology
  • Female
  • Fentanyl / pharmacology
  • Heart Rate / drug effects*
  • Male
  • Midazolam / pharmacology
  • Pentobarbital / pharmacology
  • Pregnanediones / pharmacology
  • Propofol / pharmacology
  • Rats
  • Respiration / drug effects*
  • Thiopental / analogs & derivatives
  • Thiopental / pharmacology


  • Anesthetics
  • Butyrophenones
  • Pregnanediones
  • fluanisone
  • alphaxalone
  • thiobarbital
  • Pentobarbital
  • Thiopental
  • alphadolone
  • Midazolam
  • Fentanyl
  • Propofol