Limb deficiency with or without Möbius sequence in seven Brazilian children associated with misoprostol use in the first trimester of pregnancy

Am J Med Genet. 1993 Aug 1;47(1):59-64. doi: 10.1002/ajmg.1320470113.


Misoprostol, a synthetic analog of prostaglandin, has been widely used in Brazil as an abortifacient. Abortion is illegal in Brazil. An uncertain number of these abortion attempts are unsuccessful and the pregnancy continues. We report on 7 patients whose mothers attempted to abort using this drug in the first trimester of gestation without success. The 7 patients presented with limb defects and in 4 of them a diagnosis of Möbius sequence was made.

Publication types

  • Case Reports

MeSH terms

  • Abnormalities, Drug-Induced*
  • Abnormalities, Multiple / chemically induced*
  • Abortion, Criminal
  • Brazil
  • Cranial Nerve Diseases / chemically induced
  • Cranial Nerve Diseases / congenital*
  • Ectromelia / chemically induced*
  • Facial Paralysis / chemically induced
  • Facial Paralysis / congenital*
  • Female
  • Foot Deformities, Congenital / chemically induced
  • Hand Deformities, Congenital / chemically induced
  • Humans
  • Infant, Newborn
  • Male
  • Misoprostol / adverse effects*
  • Pregnancy
  • Syndrome


  • Misoprostol