Contrasting distributions of patched and hedgehog proteins in the Drosophila embryo

Mech Dev. 1993 Jul;42(1-2):89-96. doi: 10.1016/0925-4773(93)90101-3.


The segment polarity genes patched (ptc) and hedgehog (hh) are thought to encode a receptor and signal molecule respectively, components of a signal transduction pathway that regulates the transcription of the wingless gene in the Drosophila embryo. Here we describe the production of antibodies specific for the products of these two genes and the patterns of protein distribution that they reveal in the developing embryo. The results are consistent with the hh protein being secreted by cells in which it is expressed and support a role for ptc in the reception of the putative hh encoded signal.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antibodies, Monoclonal
  • Antibody Specificity
  • Drosophila / embryology
  • Drosophila / metabolism*
  • Drosophila Proteins*
  • Embryo, Nonmammalian / metabolism
  • Embryonic Development
  • Insect Hormones / metabolism*
  • Membrane Proteins / metabolism*
  • Proteins / metabolism*
  • Receptors, Cell Surface
  • Signal Transduction / genetics*


  • Antibodies, Monoclonal
  • Drosophila Proteins
  • Insect Hormones
  • Membrane Proteins
  • Proteins
  • Receptors, Cell Surface
  • ptc protein, Drosophila