Midline cerebral malformations and schizophrenia

J Neuropsychiatry Clin Neurosci. Summer 1993;5(3):287-93. doi: 10.1176/jnp.5.3.287.

Abstract

To investigate a possible association of midline cerebral malformations with psychotic disorders, MRI and CT scans were blindly evaluated for 52 patients with schizophrenia, 9 with schizoaffective disease, and 79 consecutive nonpsychotic control subjects. Midline abnormalities were present in 10 of 61 patients (16.4%) versus 4 of 79 control subjects (5.1%; P < 0.05, chi-square). Of 52 schizophrenic patients, 8 had abnormalities of the septum pellucidum (SP): 5 had cavum vergae (CaV), 2 had cavum septum pellucidum (CaSP), and 1 had agenesis of the corpus callosum and SP. Of 9 schizoaffective patients, 2 had SP abnormalities: 1 CaV and 1 CaSP. Abnormalities of the SP, especially CaV, were significantly more frequent in women than in men (P < 0.02, chi-square).

Publication types

  • Comparative Study
  • Review

MeSH terms

  • Adult
  • Brain / abnormalities*
  • Brain / diagnostic imaging
  • Cerebral Ventricles / physiopathology
  • Female
  • Humans
  • Magnetic Resonance Imaging
  • Male
  • Psychiatric Status Rating Scales
  • Psychotic Disorders / diagnosis
  • Psychotic Disorders / etiology
  • Psychotic Disorders / physiopathology*
  • Retrospective Studies
  • Schizophrenia / diagnosis
  • Schizophrenia / etiology
  • Schizophrenia / physiopathology*
  • Schizophrenic Psychology
  • Septum Pellucidum / diagnostic imaging
  • Septum Pellucidum / physiopathology*
  • Tomography, X-Ray Computed