Fifty-eight patients with acute mushroom poisoning--Amanita phalloides were treated. Among them were 28 children and 2 adolescents. From all the patients mean age was 30.5 years, 31 patients were in hepatic coma. All patients undergone conservative treatment and haemoperfusion. The mean time from beginning of acute poisoning to the first haemoperfusion was 61 hours. Ninety-eight haemoperfusions were performed, from this number 26 using Amberlite XAD-2. Seventeen simultaneous or subsequent haemodialyses and 12 plasmaphereses were performed. Mortality occurred in 20 patients (34.5%). Survival of patients depended on the amount of ingested mushroom, on the early admission of patients to dialysis centre and on the beginning of extracorporeal treatment until the period of 24 hours after acute poisoning.