The effects of warfarin on calcinosis in a patient with systemic sclerosis

J Rheumatol. 1993 Jul;20(7):1233-5.


We describe the use of low doses of warfarin to treat calcinosis in a patient with systemic sclerosis or CREST syndrome. Our patient had Raynaud's phenomenon, skin sclerosis of the neck and the distal surface of the elbows, and pitting ulcers and scarification of the fingers as well as cutaneous calcinosis. After beginning warfarin, no calcium containing substance was discharged from the fingertip ulcers. There was no tendency to bleed and activated partial thromboplastin time and prothrombin time were normal. Sequential radiographs of the hands showed that calcinosis had improved. Since there seem to be few adverse effects, the use of warfarin in patients with calcinosis warrants further study.

Publication types

  • Case Reports

MeSH terms

  • Calcinosis / complications*
  • Calcinosis / drug therapy*
  • Dose-Response Relationship, Drug
  • Female
  • Hand / diagnostic imaging
  • Humans
  • Middle Aged
  • Partial Thromboplastin Time
  • Prothrombin Time
  • Radiography
  • Scleroderma, Systemic / complications*
  • Skin Diseases / complications*
  • Skin Diseases / drug therapy*
  • Warfarin / adverse effects
  • Warfarin / therapeutic use*


  • Warfarin