Marked species-difference in the vascular angiotensin II-forming pathways: humans versus rodents

Jpn J Pharmacol. 1993 Jun;62(2):207-10. doi: 10.1254/jjp.62.207.


Using isolated arteries, we demonstrated a marked difference in the angiotensin II-forming systems between human and rodent vessels. In human arteries, only 30-40% of the conversion of angiotensin I to angiotensin II depended on the angiotensin-converting enzyme (ACE), and the rest of the angiotensin II formation was ascribed to chymostatin-sensitive angiotensin II-generating enzyme (CAGE). On the contrary, angiotensin II formation in rodent arteries totally depended upon ACE, without any sign of CAGE involvement. Such a marked species-difference can be relevant to the reported difference between humans and rodents in the ACE inhibitor effects on the myointimal hyperplasia after intimal balloon injury.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Angiotensin I / metabolism
  • Angiotensin II / biosynthesis*
  • Animals
  • Arteries / drug effects
  • Arteries / metabolism*
  • Captopril / pharmacology
  • Female
  • Humans
  • In Vitro Techniques
  • Male
  • Middle Aged
  • Oligopeptides / pharmacology
  • Rabbits
  • Rats
  • Rats, Wistar
  • Serine Endopeptidases / metabolism
  • Species Specificity


  • Oligopeptides
  • Angiotensin II
  • Angiotensin I
  • chymostatin
  • Captopril
  • Serine Endopeptidases
  • chymostatin-sensitive angiotensin II-generating enzyme