In this review, previous studies regarding the effects of cigarette smoking on parameters of physical fitness such as endurance performance, muscle strength, step test score, body mass index, blood pressure, serum lipoprotein profile, etc., have been summarized with a special reference to the quality of life for middle-aged and elder men, including the result of recent studies by the present authors. Additionally the hypothesized mechanisms of cigarette smoking to atherosclerosis have been shown. It is concluded mainly from our recent studies that: 1) the smoking has an effect to impair not only the aerobic power, but also the anaerobic power, 2) the abstention from chronic smoking would be expected to improve the parameters of physical fitness, and 3) even though the duration from the onset of smoking is less than one year, i.e., a relatively short-term smoking habit, the smoking has a serious damage to the several parameters of physical fitness.